New Paper: X-linked transcriptome dysregulation across immune cells in systemic lupus erythematosus
New publication out! We are thrilled to share our latest work, now published in Biology of Sex Differences, by our amazing collaborators: Mafalda Soares, Inês Wemans, Paulo Caldas, Simão Rocha, and Ana Rita Grosso. Systemic lupus erythematosus (SLE) predominantly affects women, and differences in X chromosome regulation may help explain why. In this paper, for the first time, the Data Integration Analysis for Biomarker Discovery using Latent cOmponents (DIABLO) was used to integrate parallel immune transcriptome profiles. This approach can help distinguish SLE patients from healthy individuals using X chromosome transcriptome dysregulation alone. Our findings also show that adaptive immune cells increase X-linked gene expression in SLE while innate immune cells decrease it, and that the reduction in expression of the central regulator (XIST lncRNA) correlates with higher expression of SLE-associated genes.
