Daniel Sobral


Daniel Sobral has a degree (2002) and MsC (2006) in Informatics
Engineering from Instituto Superior Tecnico. His passion for biology led
him to the Gulbenkian PhD Programme in Biomedicine, and to a PhD in
Bioinformatics under the supervision of Patrick Lemaire (Aix-Marseille
University, 2009). His doctoral work delved mostly on the analysis of gene
expression and transcriptional gene regulation in the context of embryonic
development of ascidians, a basal chordate. As part of his PhD, he
contributed to ANISEED, an open-access resource widely used by the
ascidian community.

After the PhD, Daniel Sobral did post-doctoral work at the European
Bioinformatics Institute, under the supervision of Ian Dunham. During this
period he designed and implemented pipelines for the analysis of hundreds
of human and mouse high throughput sequencing epigenomic datasets from
large projects such as ENCODE, and integrated results from these analysis
in ENSEMBL, one of the most widely used resources in the scientific

Since 2012 Daniel Sobral became a postdoctoral fellow at Instituto
Gulbenkian de Ciência (IGC), where he collaborated in several projects,
including the implementation of methods to detect genetic diversity in
evolving bacterial populations (in collaboration with Isabel Gordo) and
the analysis of the effect of a specific mutation in gene expression and
global splicing patterns of the developing fruitfly embryo (in
collaboration with Rui Martinho).

One important line of Daniel Sobral’s work focus on the potential impact
of epigenetics in genome evolution and organismal ontogeny. Daniel Sobral
collaborated with the laboratory of Lars Jensen studying how can
epigenetic marks be used as phenotypic memory during cellular progression.
He also collaborates with the group of Jocelyne Demengeot investigating
the connection between the epigenetic state of the genome and genomic
recombination events characteristic of adaptive immune cells. More
recently, he has been working in a project to uncover the genetic
diversity of early onset type 1 diabetes.

In 2019 Daniel Sobral moved to the group of Ana Rita Grosso at
UCIBIO/FCT-NOVA to focus on projects moving towards building bioinformatic
resources with potential practical applicability.



  • E-mail: dv.sobral [at] fct.unl.pt
  • Phone: +351 212948530 (Ext: 11114)
  • Office: 406, Departamento Ciências da Vida (FCT-NOVA)
  • Address: Departamento Ciências da Vida, Faculdade de Ciências e Tecnologia – Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal
Return to The Team