Genetic and Microenvironmental heterogeneity impacts colorectal cancer progression
Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic…
Research Highlights (8)
Glycosylation machinery is tightly regulated in healthy tissues and impaired in ageing/tumorigenesis
Glycosylation is a fundamental cellular process affecting human development and health. Complex machinery establishes the…
Innate immune evasion revealed in a colorectal zebrafish xenograft model
Cancer immunoediting is a dynamic process of crosstalk between tumor cells and the immune system.
Pan-Cancer Analysis reveals association of Genetic Heterogeneity with Epigenetic Modifiers
Intratumor genetic heterogeneity (ITH) is the main obstacle to effective cancer treatment and a major…
Transcription Dynamics Prevent RNA-Mediated Genomic Instability
Genomic instability is frequently caused by nucleic acid structures termed R-loops that are formed during…
Introns Protect Eukaryotic Genomes from Transcription-Associated Genetic Instability
Transcription is a source of genetic instability that can notably result from the formation of…
Pan-cancer analysis of MYC-PVT1 reveals CNV-unmediated deregulation
The PVT1 lncRNA has recently been involved in tumorigenesis by affecting the protein stability of…
Cancer cells ignore “stop signs”
Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However,…